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Prostate Cancer Screening

Early Detection Guidelines

The American Cancer Society, the American Urological Association, and the National Comprehensive Cancer Network recommend that health care professionals offer the option of testing for early detection of prostate cancer, prostate-specific antigen (PSA) blood test and digital rectal examination (DRE), yearly to men once they reach a certain age. They also recommend discussing the potential benefits, side effects, and questions regarding early prostate cancer detection and treatment so that men can make informed decisions about testing. The following are specific recommendations by these organizations:

American Cancer SocietyWhat the American Cancer Society Recommends

 Annual PSA and DRE

  • Begin at age 50
    • Anticipated life expectancy of 10 years or more
  • Begin at age 45 (high risk)
    • First degree relative (father, brother, son) diagnosed with prostate cancer at early age (before age 65)
    • African-American
  • Begin at age 40 (higher risk)
    • Multiple first degree relatives (father, brother, son) diagnosed with prostate cancer at early age (before age 65)

What the American Urological Association Recommends

AUAAnnual PSA and DRE

  • Begin at age 50
    • Anticipated life expectancy of 10 years or more
  • Begin at age 45 (high risk)
    • First degree relative (father, brother, son) diagnosed with prostate cancer at early age (before age 65)
    • African-American
  • Begin at age 40 (higher risk)
    • Multiple first degree relatives (father, brother, son) diagnosed with prostate cancer at early age (before age 65)
    • PSA < 1.0 ng/mL, no additional testing until age 45
    • PSA > 1.0 ng/mL but < 2.5 ng/dl, annual testing
    • PSA ≥ 2.5 ng/mL, further evaluation with biopsy

What the National Comprehensive Cancer Network Recommends

NCCNAnnual PSA and DRE

  • Begin at age 50
    • Anticipated life expectancy of 10 years or more
  • Begin at age 45
    • African-American
    • Two or more first degree relatives (father, brother, son)
    • PSA > 0.6 ng/mL at age 45
  • Begin at age 40
    • PSA > 0.6 ng/mL at baseline screening

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